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KMID : 1004520120280020171
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Journal of Dental Rehabilitation and Applied Science
2012 Volume.28 No. 2 p.171 ~ p.178
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Analgesic Effect of Botulinum Toxin on Neuropathic Pain after Trigeminal Nerve Injury
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Kim Young-Gun
Kim Seong-Taek
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Abstract
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Botulinum toxin type A (BoNT-A) has been applied successfully to treat chronic migraine, dystonia, spasticity and
temporomandubular disorders(TMDs) as well as frontal wrinkle and glabella wrinkle. Recently it has been reported that
BoNT-A, reversibly blocks presynaptic acetylcholine release, also inhibits the release of substance P, CGRP(calcitonin gene related peptide) and glutamate related to peripheral sensitization and neurogenic inflammation in sensory nerve, In this study we reviewed animal nerve injury model such as rat and rabbit and identify the analgesic effect and mechanism of nerve injury pain after dental treatment.
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KEYWORD
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botulinum toxin, pain, nerve injury
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